Research problem:
Is it possible to synthesize more potent inhibitors with more favorable ADMET profiles than PJ34 to inhibit exotoxin A in the context of pharmacology to combat nosocomial infections caused by the bacterium Pseudomonas aeruginosa ?
Hypothesis:
According to Yates et al. (2005), there is a possibility that derivatives of the compound PJ34 with a longer R group could be more potent inhibitors. Thus, the present research has the following basic hypothesis: by extending the R group of PJ34 , it is possible to synthesize derivatives of this substance that are more potent inhibitors of exotoxin A and with an ADMET profile more suitable for treating nosocomial infections of Pseudomonas aeruginosa . Therefore, these derivatives would be candidates for new methods of treating P. aeruginosa infections, generating new types of more effective drugs to combat more severe symptoms.
YATES, Susan P. et al. Structure–function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa. Biochemical Journal , vol. 385, no. 3, p. 667-675, 2005. Available at: < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134741/ >. Accessed on: 6 Aug. 2024.
Comments