The main difference between Gram-negative bacteria and Gram-positive bacteria is the composition of the cell wall. In addition to the cell wall and the cytoplasmic membrane, Gram-negative bacteria also have an outer membrane, which is not common in Gram-positive bacteria. The presence of this membrane alters the bacteria's reaction to antibiotics, since, by acting as a permeability barrier, this outer membrane can prevent the penetration of some drugs. Therefore, Gram-negative bacteria have inherent resistance to some antibiotics because of the outer membrane. (EXNER et al., 2017)
An example of Gram-negative bacteria is Pseudomonas aeruginosa, which is the focus of REACT.
EXNER, M. et al. Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria? GMS hygiene and infection control , v. 12, no. 1, p. Doc05, 2017. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388835/ . Accessed on: 4 Aug. 2024.
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