top of page

Gram-negative bacteria

Writer: Gabriela Goes da CunhaGabriela Goes da Cunha

The main difference between Gram-negative bacteria and Gram-positive bacteria is the composition of the cell wall. In addition to the cell wall and the cytoplasmic membrane, Gram-negative bacteria also have an outer membrane, which is not common in Gram-positive bacteria. The presence of this membrane alters the bacteria's reaction to antibiotics, since, by acting as a permeability barrier, this outer membrane can prevent the penetration of some drugs. Therefore, Gram-negative bacteria have inherent resistance to some antibiotics because of the outer membrane. (EXNER et al., 2017)

An example of Gram-negative bacteria is Pseudomonas aeruginosa, which is the focus of REACT.






EXNER, M. et al. Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria? GMS hygiene and infection control , v. 12, no. 1, p. Doc05, 2017. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388835/ . Accessed on: 4 Aug. 2024.

 
 
 

Recent Posts

See All

Superbugs

The term superbugs, or multidrug-resistant bacteria, refers to antimicrobial resistance, which is characterized by the ability of these...

Pseudomonas aeruginosa

The Gram-negative superbug Pseudomonas aeruginosa does not usually cause infections in healthy people. However, this bacterium can...

Exotoxin A

Exotoxin A is essential in the pathogenesis of P. aeruginosa , it is a NAD-dependent ADP-ribosyltransferase that inactivates eukaryotic...

Commentaires


images.png

R.E.A.C.T (Revolutionary Exotoxin A Combat Techniques): Design de inibidores da Exotoxina A da Pseudomonas aeruginosa projetados com Docking Molecular e in silico ADMET contra superbactérias de infecções nosocomiais (infecções hospitalares). © 2024 by Gabriela Goes da Cunha and Júlia Silva Djahjah is licensed under Creative Commons Attribution 4.0 International

bottom of page